Microgest 200mg Capsule 10pcs

Uses of Microgest 200mg Capsule

• Treatment of Female infertility
• Female hormonal imbalance.

How does Microgest 200mg Capsule work?

Microgest is a steroid hormone used to manage progesterone deficiency in the body. It supplements your body with sufficient levels of progesterone required for the successful implantation of a fertilized egg in the uterus and for the maintenance of an early pregnancy. It sustains pregnancy among infertile women by increasing the thickness of the uterine wall. It also regulates the hormonal balance in the body and corrects abnormal uterine bleeding and other menstrual problems caused due to incorrect levels of progesterone in the body.

Side Effects of Microgest 200mg Capsule

Microgest is devoid of estrogenic, androgenic, and mineralocorticoid effects. Reported side effects include mild somnolence, depression, breast tenderness, and bloating. Side effects are less when the vaginal route is used.

Quick Suggestions:

• Microgest 200mg Softgel Capsule is a natural progesterone available as a micronized formulation which helps in better absorption of this medicine.
• It is used as a part of hormone replacement therapy generally in combination with estrogen.
• It may also be used in the treatment of problems related to menstrual periods such as amenorrhea (absence of periods).
• It also helps in the maintenance of pregnancy in women who are at higher risk of miscarriage.
• It should be taken with food.
• It may cause sleepiness or drowsiness. If this happens to you, do not drive or use machinery.

Indication of Microgest 200mg Capsule

Microgest soft gel capsule is indicated for:

• Maintenance of pregnancy in cases of threatened or recurrent abortion.
• Luteal support during intrauterine insemination (IUI) and assisted reproductive technology (ART) procedures such as in vitro fertilization and embryo transfer (IVF-ET).
• Luteal support in cases of proven luteal phase insufficiency.
• Along with estrogen in post-menopausal hormone replacement therapy (HRT) in either a sequential or continuous regimen.
• Prevention of endometrial hyperplasia where endogenous estrogen is present.
• Progesterone challenge test in secondary amenorrhoea.
• Cycle control along with estrogen therapy.
• Dysfunctional uterine bleeding (DUB).
• Premenstrual tension.
• Endometriosis.
• Oocyte donation program.
• Benign mastopathy.

Pharmacology

Progesterone micronized soft gel capsules contain micronized progesterone, which is structurally and biologically identical to natural endogenous progesterone. Micronisation increases the bioavailability of progesterone. When administered after meals, maximal serum progesterone levels are significantly increased. Progesterone concentrations in the endometrial and breast tissue attain high levels. Approximately 96%-99% of progesterone is bound to serum proteins, primarily serum albumin (50%-54%). Progesterone is metabolized to pregnanediols and pregnanolones in the liver. The glucuronide and sulfate conjugates of pregnanediol and pregnanolone are excreted in the bile and urine. Progesterone metabolites excreted in bile may undergo enterohepatic circulation.

Dosage & Administration of Microgest 200mg Capsule

The usual recommended dose: Progesterone 100 mg/200 mg, 2 to 3 soft gel capsules daily by the oral or vaginal routes in divided doses. Flexible dosage regimen can be followed depending on the indication and patient requirements.

• Maintenance of Pregnancy in Threatened / Recurrent Abortion: Progesterone 200 to 400 mg per day in divided doses.
• In-vitro Fertilization and Embryo Transfer: Progesterone 200 mg thrice a day from the day of embryo transfer till pregnancy is confirmed. If pregnant, it is continued till the 12th week of pregnancy.
• HRT:
  • Sequential regimen: Progesterone 200 mg daily for 12 days in the last 2 weeks of each therapeutic cycle.
  • Continuous regimen: Progesterone 100 mg daily throughout the month along with estrogen.
• Oocyte Donation Program: Progesterone 100 mg twice daily from the day of transfer till pregnancy is confirmed. This may be increased to a maximum of 600 mg per day and continued till the 12th week of pregnancy.
• Luteal Support: Progesterone 100 mg thrice a day from the 17th day of the cycle for 10 days in an induced cycle. If pregnant, it is continued till the 12th week of pregnancy.
• Luteal Phase Insufficiency: Progesterone 100 mg thrice daily to be continued up to 12 weeks of pregnancy, increasing the dose by 100 mg/day/week to a maximum of 600 mg/day in divided doses if required.
• Secondary Amenorrhoea: Progesterone 300 mg for 10 days results in withdrawal bleeding in 80% of cases.
• Premenstrual Syndrome: Progesterone 100-200 mg daily for 10 days from the 17th to 26th day of each menstrual cycle.
• Benign Mastopathy: Progesterone 200-300 mg for 10 days per month, usually from the 17th to 26th day of the monthly cycle.

Always follow the doctor’s advice when taking medication.

Drug-Drug Interactions

Microgest 200mg capsule may interact with:

• Anticonvulsants: Carbamazepine, phenytoin, phenobarbital
• Anti-tuberculosis drugs: Rifabutin, rifampicin
• Anti-HIV drugs: Ritonavir, nevirapine, nelfinavir, efavirenz
• Benzodiazepine: Diazepam
• Diuretics (water tablet): Spironolactone
• Immunosuppressant: Ciclosporin
• Blood thinners: Phenindione
• Skeletal muscle relaxants: Tizanidine
• Antifungals: Terbinafine, ketoconazole, griseofulvin

Drug-Food Interaction

• Herbal Supplements: Microgest 200mg capsule may interact with St. John’s wort, an herbal supplement used to treat depression.

Contraindications

Inform your doctor if you are allergic to soya, Microgest 200mg capsule, or any other medications.

• Do not use if you have:
  • Breast cancer
  • Unexplained vaginal bleeding
  • Blood clots or blood clotting disorder
  • Liver disease
  • Porphyria (a disorder in the formation of red blood pigment)
  • Cerebral hemorrhage (bleeding in the brain)
  • Are pregnant, as it may harm the unborn baby

Drug-Disease Interactions

Avoid taking Microgest 200mg capsule if you have:

• Breast cancer
• Unexplained vaginal bleeding
• Blood clots or blood clotting disorder
• Liver disease
• Porphyria
• Cerebral hemorrhage
• Diabetes
• High blood pressure
• Migraine or severe headaches
• Gallstones
• Asthma
• Fits
• Systemic lupus erythematosus
• History of depression

Pregnancy and Breastfeeding

• Pregnancy: Avoid using Microgest 200mg capsule if you are pregnant. Use effective birth control methods to prevent pregnancy while taking this medication. Consult your doctor if you are planning for pregnancy or are pregnant.
• Breastfeeding: Consult your doctor before using Microgest 200mg capsule if you are breastfeeding.

Side Effects and Precautions

Common Side Effects: Drowsiness or dizziness. Avoid driving or operating machinery if you experience these symptoms.

• Inform your doctor if you have:
  • Diabetes
  • High blood pressure
  • Migraine or severe headaches
  • Gallstones
  • Asthma
  • Fits
  • Systemic lupus erythematosus (an autoimmune disease)
  • History of depression

Pre-surgery Information

• If you are about to undergo surgery, inform your doctor that you are taking a Microgest 200mg capsule.

Storage Conditions:

• Keep below 30°C.
• Store away from light and moisture.
• Keep out of the reach of children.